Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 11/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4985493 | 0.91 | EPHX2 (0.35) | NTRK1GRM2 | |
| SCHEMBL4989382 | 0.90 | LMNA (0.38) | ALDH1A1 | |
| SCHEMBL4988694 | 0.89 | EPHX2 (0.39) | GPR6GRM2 | |
| SCHEMBL4982656 | 0.85 | P2RX7 (0.38) | ALDH1A1 | |
| SCHEMBL14272268 | 0.85 | P2RX7 (0.40) | — | |
| SCHEMBL5141408 | 0.85 | P2RX7 (0.38) | — | |
| SCHEMBL4991840 | 0.84 | BRS3 (0.37) | ALDH1A1 | |
| SCHEMBL5145755 | 0.83 | P2RX7 (0.38) | ALDH1A1 | |
| SCHEMBL14272270 | 0.82 | EPHX2 (0.39) | — | |
| SCHEMBL4985453 | 0.82 | CXCR3 (0.47) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |