Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129657 | 0.72 | ALDH1A1 (0.39) | PDE3BPDE3AHPGDPKMALDH1A1 | |
| SCHEMBL11655 | 0.72 | NISCH (0.48) | GAAGFERKDM4EHPGDPKM | |
| SCHEMBL10810557 | 0.71 | PDE3B (1.00) | PDE3BPDE3ACDK5CDK5R1TDO2 | |
| SCHEMBL1133436 | 0.69 | GAA (0.50) | PDE3BPDE3AGAAHPGDALDH1A1 | |
| SCHEMBL7454459 | 0.69 | PDE3B (0.50) | PDE3BPDE3AGAAHPGDALDH1A1 | |
| SCHEMBL17269663 | 0.69 | GAA (0.47) | GAAGFERKDM4EHPGDPKM | |
| SCHEMBL18225434 | 0.68 | GAA (0.54) | GAAKDM4EHPGDALDH1A1MEN1 | |
| SCHEMBL28606824 | 0.68 | NOTUM (0.48) | PDE3BPDE3AGAAGFERKDM4E | |
| SCHEMBL25754931 | 0.68 | PIN1 (0.58) | KDM4EHPGDPKMALDH1A1MEN1 | |
| SCHEMBL27880566 | 0.68 | CDK5 (0.41) | PKMALDH1A1CDK5CDK5R1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |