Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.58 |
| ▸ | ERCC1 | P07992 | 4/20 | 0.50 |
| ▸ | FEN1 | P39748 | 4/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3057838 | 0.74 | PIN1 (1.00) | PIN1ERCC1FEN1ERCC4CYP1A2 | |
| SCHEMBL17269663 | 0.73 | GAA (0.47) | MEN1KMT2AKDM4EHPGDPKM | |
| SCHEMBL13175051 | 0.72 | SCN2A (0.62) | MEN1KMT2AKDM4EHPGDMAPT | |
| SCHEMBL497462 | 0.72 | SLC7A5 (0.43) | ERCC1FEN1ERCC4KDM4EHPGD | |
| SCHEMBL28061565 | 0.72 | SLC7A5 (0.43) | ERCC1FEN1ERCC4KDM4EHPGD | |
| SCHEMBL7565683 | 0.71 | KMT2A (0.55) | ERCC1FEN1ERCC4MEN1KMT2A | |
| SCHEMBL25754942 | 0.71 | PIN1 (0.63) | PIN1DHODHDAO | |
| SCHEMBL22027680 | 0.70 | ERCC1 (0.68) | PIN1ERCC1FEN1ERCC4MEN1 | |
| SCHEMBL1896303 | 0.69 | PIN1 (0.65) | PIN1KDM4EHPGDPKMALDH1A1 | |
| SCHEMBL25754920 | 0.69 | SMN1; SMN2 (0.50) | MEN1KMT2AKDM4EHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | PIN1 3482/4885ERCC1 3705/4885FEN1 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.