Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 9/20 | 0.76 |
| ▸ | GSK3B | P49841 | 9/20 | 0.76 |
| ▸ | TTR | P02766 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 5/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | APEX1 | P27695 | 4/20 | 0.63 |
| ▸ | RECQL | P46063 | 3/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | PRF1 | P14222 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145124 | 1.00 | GSK3A (0.76) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL5147289 | 0.91 | GSK3A (0.76) | GSK3AGSK3BKMT2AKDM4EPOLB | |
| SCHEMBL5147286 | 0.91 | GSK3A (0.76) | GSK3AGSK3BKMT2AKDM4EPOLB | |
| SCHEMBL5145154 | 0.88 | GSK3A (0.78) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL5145152 | 0.88 | GSK3A (0.78) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL15506584 | 0.86 | GSK3A (1.00) | GSK3AGSK3BKMT2AL3MBTL1MEN1 | |
| SCHEMBL3360967 | 0.82 | TTR (0.82) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL30657767 | 0.82 | TTR (0.82) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL3360964 | 0.82 | TTR (0.82) | GSK3AGSK3BTTRKMT2AKDM4E | |
| SCHEMBL12989661 | 0.82 | TTR (0.82) | GSK3AGSK3BTTRKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-12-22 | — | — | US | disclosed |
| US-6943188-B2 | Hydroxyalkyl compounds | ASTRAZENECA AB (SE) | 2005-09-13 | — | — | US | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |
| US-20030149047-A1 | Novel compounds | ASTRAZENCA AB (SE) | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149047-A1 | Novel compounds | RPS4Y1, RPS4X, RPS6 | GSK3A 2650/4885GSK3B 2220/4885TTR 3405/4885 |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | GSK3A 2087/4885GSK3B 2118/4885TTR 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.