Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145323 | 0.90 | MEN1 (0.53) | MEN1KMT2AF2L3MBTL1POLB | |
| SCHEMBL3690532 | 0.82 | MEN1 (0.63) | MEN1KMT2AF2L3MBTL1POLB | |
| SCHEMBL5180672 | 0.80 | CNR1 (0.67) | — | |
| SCHEMBL5146669 | 0.80 | MEN1 (0.60) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5145068 | 0.80 | MEN1 (0.47) | MEN1KMT2AF2L3MBTL1POLB | |
| SCHEMBL5145123 | 0.78 | PGR (0.53) | MEN1KMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5146880 | 0.77 | MAPT (0.59) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5147423 | 0.76 | KMT2A (0.56) | MEN1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5145213 | 0.75 | CA1 (0.54) | MEN1KMT2ACYP19A1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9942084 | 0.75 | ALDH1A1 (0.60) | MEN1KMT2AL3MBTL1POLBKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663113-A4 | SUBSTITUTED SULFONAMIDES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1663113-A2 | SUBSTITUTED SULFONAMIDES | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005027837-A2 | SUBSTITUTED SULFONAMIDES | MERCK & CO., INC. (US) | 2005-03-31 | — | — | WO | claimed |