Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146876 | 0.92 | SLC6A2 (0.44) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL5145543 | 0.92 | SLC6A2 (0.44) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL5147333 | 0.85 | CA1 (0.40) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL5147379 | 0.74 | SLC6A2 (0.41) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL5143570 | 0.74 | SLC6A2 (0.41) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL5146669 | 0.73 | MEN1 (0.60) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL12601602 | 0.72 | HTR2A (0.52) | ALDH1A1LMNAKMT2ANPSR1SLC6A3 | |
| SCHEMBL5145190 | 0.72 | MEN1 (0.64) | MAPTALDH1A1LMNAPOLBKMT2A | |
| SCHEMBL5147423 | 0.71 | KMT2A (0.56) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL5145330 | 0.70 | CNR1 (0.46) | ALDH1A1KMT2ASLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663113-A4 | SUBSTITUTED SULFONAMIDES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1663113-A2 | SUBSTITUTED SULFONAMIDES | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005027837-A2 | SUBSTITUTED SULFONAMIDES | MERCK & CO., INC. (US) | 2005-03-31 | — | — | WO | claimed |