Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145543 | 0.95 | SLC6A2 (0.44) | CA1CA2CNR1CNR2SLC6A2 | |
| SCHEMBL5146876 | 0.95 | SLC6A2 (0.44) | CA1CA2CNR1CNR2SLC6A2 | |
| SCHEMBL5145233 | 0.85 | MAPT (0.37) | GRIA4SLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL5145391 | 0.84 | CNR2 (0.36) | CA1CA2CNR1GRIA4CNR2 | |
| SCHEMBL5147402 | 0.81 | CA1 (0.63) | CA1CA2MEN1KMT2AALDH1A1 | |
| SCHEMBL5147379 | 0.78 | SLC6A2 (0.41) | CA1CA2CNR1CNR2SLC6A2 | |
| SCHEMBL5143570 | 0.78 | SLC6A2 (0.41) | CA1CA2CNR1CNR2SLC6A2 | |
| SCHEMBL5147423 | 0.77 | KMT2A (0.56) | CA1CA2GRIA4MEN1KMT2A | |
| SCHEMBL5147491 | 0.77 | CA1 (0.51) | CA1CA2CNR1CNR2MEN1 | |
| SCHEMBL5147331 | 0.77 | RAB9A (0.43) | CA1CA2CNR1CNR2PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663113-A4 | SUBSTITUTED SULFONAMIDES | MERCK & CO INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1663113-A2 | SUBSTITUTED SULFONAMIDES | Merck & Co., Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005027837-A2 | SUBSTITUTED SULFONAMIDES | MERCK & CO., INC. (US) | 2005-03-31 | — | — | WO | claimed |