Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 1.00 |
| ▸ | GSK3A | P49840 | 4/20 | 0.80 |
| ▸ | GSK3B | P49841 | 4/20 | 0.80 |
| ▸ | BRAF | P15056 | 4/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587001 | 0.89 | SIRT2 (0.80) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL1064843 | 0.89 | GSK3A (0.81) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL15506584 | 0.89 | GSK3A (1.00) | SIRT2GSK3AGSK3BBRAFMEN1 | |
| SCHEMBL5145235 | 0.86 | AURKA (0.78) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL31061383 | 0.86 | SIRT2 (0.75) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL13056375 | 0.86 | SIRT2 (0.75) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL13056364 | 0.85 | SIRT2 (1.00) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL15502298 | 0.84 | SIRT2 (0.73) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL5991954 | 0.81 | SIRT2 (0.69) | SIRT2GSK3AGSK3BBRAFAURKA | |
| SCHEMBL5997094 | 0.80 | BRAF (1.00) | SIRT2GSK3AGSK3BBRAFAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065139-A2 | ENTPD5 INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-05-18 | — | — | WO | disclosed |
| US-20100298390-A1 | INHIBITION OF LETHAL FACTOR PROTEASE ACTIVITY FROM ANTHRAX TOXIN | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100298390-A1 | INHIBITION OF LETHAL FACTOR PROTEASE ACTIVITY FROM ANTHRAX TOXIN | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-11-25 | — | — | US | disclosed |
| US-7718680-B2 | Inhibition of lethal factor protease activity from anthrax toxin | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718680-B2 | Inhibition of lethal factor protease activity from anthrax toxin | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080033025-A1 | Inhibition of lethal factor protease activity from anthrax toxin | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-02-07 | — | — | US | disclosed |
| US-20080033025-A1 | Inhibition of lethal factor protease activity from anthrax toxin | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298390-A1 | INHIBITION OF LETHAL FACTOR PROTEASE ACTIVITY FROM ANTHRAX TOXIN | APAF1, ANTXR2, SERPINB1 | SIRT2 2103/4885GSK3A 3193/4885GSK3B 3202/4885 |
| US-20080033025-A1 | Inhibition of lethal factor protease activity from anthrax toxin | APAF1, ANTXR2, SERPINB1 | SIRT2 2103/4885GSK3A 3193/4885GSK3B 3202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.