SCHEMBL514644

SCHEMBL514644

Cc1ccc(OC[C]=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
GRM5 P41594 1/20 0.45
DRD2 P14416 1/20 0.44
DRD4 P21917 1/20 0.44
DRD3 P35462 1/20 0.44
WDR5 P61964 1/20 0.44
HPGD P15428 2/20 0.43
MAPT P10636 1/20 0.43
ACHE P22303 1/20 0.42
LMNA P02545 2/20 0.42
MAOB P27338 1/20 0.42
GAA P10253 1/20 0.42
TSHR P16473 2/20 0.41
CYP3A4 P08684 1/20 0.41
KCNH2 Q12809 1/20 0.41
NPC1 O15118 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
PARP10 Q53GL7 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2170360 0.88 CA12 (0.42) L3MBTL1MAPTACHELMNAMAOB
SCHEMBL2641343 0.82 CA12 (0.50) GRM5MAPTACHELMNA
SCHEMBL10947087 0.82 NQO1 (0.64) MAPTLMNATSHRNPC1PARP10
SCHEMBL5254783 0.78 LTA4H (0.52) TSHRCYP3A4
SCHEMBL21052116 0.78 L3MBTL1 (0.53) L3MBTL1DRD2DRD4DRD3WDR5
SCHEMBL12314512 0.77 GRM5 (0.53) L3MBTL1GRM5DRD2DRD4DRD3
SCHEMBL2641227 0.77 LTA4H (0.47) LMNA
SCHEMBL6978990 0.77 TDP1 (0.52) L3MBTL1MAPTMAOBGAATSHR
SCHEMBL514661 0.77 APP (0.42) DRD2DRD4DRD3MAPTMAOB
SCHEMBL3357599 0.77 ALDH1A1 (0.46) L3MBTL1GRM5DRD2DRD4DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 189 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0675895-B1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER PF MEDICAMENT (FR) 1997-07-23 EP claimed
US-5643885-A Etoposide derivatives, process for preparing them, their use as a medicinal product and their use for the preparation of a medicinal product intended for anti-cancer treatment PIERRE FABRE MEDICAMENT (FR) 1997-07-01 US claimed
JP-H08504795-A 1996-05-21 JP claimed
EP-0675895-A1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER. FABRE PIERRE COSMETIQUE (FR) 1995-10-11 EP claimed
EP-0469888-B1 Amidobenzenes ICI PLC (GB) 1994-09-28 EP claimed
WO-1994014829-A1 ETOPOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A DRUG AND IN THE PREPARATION OF A DRUG FOR TREATING CANCER PIERRE FABRE MEDICAMENT (FR) 1994-07-07 WO claimed
US-5250570-A Aldose reductase inhibitors for controlling side effects of diabetes and galactosemia IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-05 US claimed
EP-0498680-A1 New beta-amino-alpha-hydroxycarboxylic acids and their use Sankyo Company Limited (JP) 1992-08-12 EP claimed
EP-0469888-A1 Amidobenzenes IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-02-05 EP claimed
JP-6135989-A None JP disclosed
WO-2024129931-A1 ALPHA-V BETA-6(ανβ6) INTEGRIN LIGANDS FOR EXTRAHEPATIC DELIVERY ALNYLAM PHARMACEUTICALS, INC. (US) 2024-06-20 WO disclosed
CN-113316398-B Seamless capsule, filter and smoking article comprising same 三生医药株式会社 2024-06-11 CN disclosed
CN-117120042-A Seamless capsule capable of stably disintegrating even in high-temperature and high-humidity environment and method for producing same 森下仁丹株式会社 2023-11-24 CN disclosed
WO-2023210623-A1 HALOALKYL SULFONE ANILIDE COMPOUND AND HERBICIDE CONTAINING SAME 株式会社エス・ディー・エス バイオテック 2023-11-02 WO disclosed
US-3992377-A 3-Thio-substituted cephalosporin antibiotics ELI LILLY AND COMPANY (US) 1976-11-16 US disclosed
US-3988325-A 7-Carboxy or 2,2,2-trichloroethoxy carbonyl- cephalosporins ELI LILLY AND COMPANY (US) 1976-10-26 US disclosed
US-3985737-A ANTIBACTERIAL AGENTS ELI LILLY AND COMPANY (US) 1976-10-12 US disclosed
US-3962227-A ANTIBIOTICS ELI LILLY AND COMPANY (US) 1976-06-08 US disclosed
US-3962214-A Process for preparing amino substituted β-lactam antibiotics ELI LILLY AND COMPANY (US) 1976-06-08 US disclosed
US-3954731-A Process for preparing 6-alkoxypenicillanic and 7-alkoxycephalosporin acids ELI LILLY AND COMPANY (US) 1976-05-04 US disclosed