SCHEMBL5146947

SCHEMBL5146947

CON[C@@H](C)C(=O)OP(=O)(O)O

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 2/20 0.35
MMP2 P08253 2/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35
CA9 Q16790 1/20 0.35
PEPD P12955 1/20 0.35
CA4 P22748 1/20 0.34
CA14 Q9ULX7 1/20 0.33
MMP3 P08254 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5050593 0.84 CA12 (0.33) MMP1MMP2CA12CA1CA2
SCHEMBL29852867 0.84 CA12 (0.33) MMP1MMP2CA12CA1CA2
SCHEMBL28455795 0.84 CA12 (0.33) MMP1MMP2CA12CA1CA2
SCHEMBL12503915 0.82 PEPD (0.34) MMP1MMP2CA12CA1CA2
SCHEMBL16223471 0.80 CA12 (0.37) MMP1MMP2CA12CA1CA2
SCHEMBL16223469 0.80 CA12 (0.37) MMP1MMP2CA12CA1CA2
SCHEMBL6234114 0.77
SCHEMBL16647323 0.77
SCHEMBL7027239 0.75 MMP1 (0.37) MMP1MMP2CA12CA1CA2
SCHEMBL7771208 0.74 PKM (0.31) MMP1CA12CA1CA2MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551420-A4 ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV PARKER HUGHES INST (US) 2007-11-21 EP disclosed
EP-1551420-A1 ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV Parker Hughes Institute (US) 2005-07-13 EP disclosed
EP-1090018-B1 ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY PARKER HUGHES INST (US) 2004-09-29 EP disclosed
WO-2003105863-A1 ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV PARKER HUGHES INSTITUTE (US) 2003-12-24 WO disclosed
EP-1090018-A1 ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY Parker Hughes Institute (US) 2001-04-11 EP disclosed
EP-1068215-A1 AZT DERIVATIVES EXHIBITING SPERMICIDAL AND ANTI-VIRAL ACTIVITY Parker Hughes Institute (US) 2001-01-17 EP disclosed
WO-2000000501-A1 ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ANTI-HIV ACTIVITY PARKER HUGHES INSTITUTE (US) 2000-01-06 WO disclosed
WO-1999048902-A1 AZT DERIVATIVES EXHIBITING SPERMICIDAL AND ANTI-VIRAL ACTIVITY PARKER HUGHES INSTITUTE (US) 1999-09-30 WO disclosed