Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147388 | 0.88 | ALDH1A1 (0.41) | ALDH1A1EIF2AK2CDK2CLK1MAPK1 | |
| SCHEMBL2978487 | 0.87 | EIF2AK2 (0.37) | ALDH1A1EIF2AK2CDK2CLK1MAPK1 | |
| SCHEMBL5148871 | 0.78 | ALDH1A1 (0.40) | ALDH1A1CDK2CLK1HTT | |
| SCHEMBL5147410 | 0.75 | ALDH1A1 (0.41) | ALDH1A1CDK2CLK1KDM4EHTT | |
| SCHEMBL2984010 | 0.75 | EIF2AK2 (0.39) | EIF2AK2CDK2CLK1RAF1BRAF | |
| SCHEMBL5147395 | 0.74 | CDK2 (0.38) | ALDH1A1CDK2CLK1POLBMAPK1 | |
| SCHEMBL5147359 | 0.74 | ALDH1A1 (0.45) | ALDH1A1CDK2CLK1KDM4ELMNA | |
| SCHEMBL5148412 | 0.72 | ALDH1A1 (0.37) | ALDH1A1CDK2CLK1MAPK1L3MBTL1 | |
| SCHEMBL5147312 | 0.72 | IKBKB (0.42) | ALDH1A1CDK2CLK1POLBMAPK1 | |
| SCHEMBL5147497 | 0.71 | AKT3 (0.41) | ALDH1A1HTR7EIF2AK2CDK2CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |