Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147388 | 0.87 | ALDH1A1 (0.41) | ALDH1A1CDK2CLK1SMN1; SMN2NPC1 | |
| SCHEMBL2986650 | 0.85 | CDK2 (0.37) | CDK2CLK1MKNK1 | |
| SCHEMBL5147410 | 0.82 | ALDH1A1 (0.41) | ALDH1A1CDK2CLK1SMN1; SMN2RAB9A | |
| SCHEMBL5147395 | 0.82 | CDK2 (0.38) | ALDH1A1CDK2CLK1SMN1; SMN2PLA2G7 | |
| SCHEMBL5182109 | 0.79 | ALDH1A1 (0.42) | ALDH1A1CDK2CLK1SMN1; SMN2NPC1 | |
| SCHEMBL5147359 | 0.79 | ALDH1A1 (0.45) | ALDH1A1CDK2CLK1SMN1; SMN2NPC1 | |
| SCHEMBL5147312 | 0.79 | IKBKB (0.42) | ALDH1A1CDK2CLK1SMN1; SMN2RAB9A | |
| SCHEMBL5147284 | 0.78 | ALDH1A1 (0.36) | ALDH1A1CDK2CLK1HTT | |
| SCHEMBL5147468 | 0.77 | SMN1; SMN2 (0.40) | ALDH1A1CDK2CLK1SMN1; SMN2NPC1 | |
| SCHEMBL5181846 | 0.77 | AKT3 (0.37) | ALDH1A1CDK2CLK1SMN1; SMN2PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |