Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179013 | 0.92 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5182109 | 0.89 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5147468 | 0.86 | SMN1; SMN2 (0.40) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5147312 | 0.86 | IKBKB (0.42) | ALDH1A1RAB9ASMN1; SMN2CDK2CLK1 | |
| SCHEMBL2986435 | 0.85 | MAPK3 (0.38) | CDK2CLK1EIF2AK2MAPK1MAPK3 | |
| SCHEMBL5147462 | 0.83 | ALDH1A1 (0.42) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL5147268 | 0.82 | CDK2 (0.37) | ALDH1A1SMN1; SMN2CDK2CLK1HTT | |
| SCHEMBL5181846 | 0.82 | AKT3 (0.37) | ALDH1A1SMN1; SMN2CDK2CLK1HTT | |
| SCHEMBL5148362 | 0.81 | CDK2 (0.39) | CDK2CLK1MAPK1MAPK3 | |
| SCHEMBL5147363 | 0.80 | IKBKB (0.36) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |