Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 7/20 | 0.39 |
| ▸ | CHUK | O15111 | 5/20 | 0.37 |
| ▸ | IKBKG | Q9Y6K9 | 5/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147360 | 0.87 | CYP2A6 (0.35) | CDK2CLK1CYP2A6TGFBR1MAPK14 | |
| SCHEMBL5147363 | 0.86 | IKBKB (0.36) | CDK2CLK1IKBKBCHUKIKBKG | |
| SCHEMBL2989813 | 0.86 | IKBKB (0.38) | CDK2CLK1IKBKBCHUKIKBKG | |
| SCHEMBL5147421 | 0.84 | IKBKB (0.37) | CDK2CLK1IKBKBCHUKIKBKG | |
| SCHEMBL5147509 | 0.84 | ALDH1A1 (0.38) | CDK2CLK1IKBKBCHUKIKBKG | |
| SCHEMBL5179013 | 0.82 | ALDH1A1 (0.42) | CDK2CLK1MAPK3MAPK1 | |
| SCHEMBL5147312 | 0.82 | IKBKB (0.42) | CDK2CLK1IKBKBMAPK1 | |
| SCHEMBL5147457 | 0.81 | ALDH1A1 (0.40) | CDK2CLK1MAPK3MAPK1 | |
| SCHEMBL5149101 | 0.81 | RAF1 (0.37) | TGFBR1MAPK14 | |
| SCHEMBL5147468 | 0.80 | SMN1; SMN2 (0.40) | CDK2CLK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |