Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5179917 | 0.93 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5181987 | 0.86 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5146079 | 0.85 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL2977467 | 0.84 | GRIN1 (0.32) | GRIN1GRIN2B | |
| SCHEMBL5148393 | 0.84 | HTT (0.39) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5147457 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5147380 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5149006 | 0.82 | ADORA1 (0.39) | ALDH1A1SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL5145889 | 0.81 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL5147360 | 0.81 | CYP2A6 (0.35) | ALDH1A1SMN1; SMN2RAB9ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |