Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986238 | 0.89 | — | — | |
| SCHEMBL5147297 | 0.86 | ALDH1A1 (0.34) | ALDH1A1HTTMAPK1SMN1; SMN2 | |
| SCHEMBL5149183 | 0.81 | ALDH1A1 (0.32) | ALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL2977573 | 0.79 | — | — | |
| SCHEMBL5147380 | 0.78 | ALDH1A1 (0.40) | ALDH1A1HTTMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL5147364 | 0.75 | ALDH1A1 (0.34) | ALDH1A1HTTMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL2981942 | 0.75 | SLC6A4 (0.31) | — | |
| SCHEMBL5179917 | 0.74 | ALDH1A1 (0.40) | ALDH1A1HTTMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL5147417 | 0.73 | ALDH1A1 (0.38) | ALDH1A1HTTMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL5147377 | 0.73 | ALOX15 (0.34) | ALDH1A1HTTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |