Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 2/20 | 0.33 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148423 | 0.91 | FPR2 (0.34) | ALDH1A1LMNAMERTKPIK3CAPIK3CD | |
| SCHEMBL5145889 | 0.90 | ALDH1A1 (0.35) | ALDH1A1LMNAHTTTSHRMAPK1 | |
| SCHEMBL5147360 | 0.90 | CYP2A6 (0.35) | ALDH1A1HTTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL5147313 | 0.89 | ALDH1A1 (0.35) | ALDH1A1LMNAHTTTSHRMAPK1 | |
| SCHEMBL5183786 | 0.88 | USP2 (0.33) | LMNATSHRMERTKPIK3CAPIK3CD | |
| SCHEMBL5147498 | 0.88 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTTSHRMAPK1 | |
| SCHEMBL5148335 | 0.87 | PDE3B (0.36) | ALDH1A1LMNAHTTMAPK1NPC1 | |
| SCHEMBL5147302 | 0.87 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTNPC1SMN1; SMN2 | |
| SCHEMBL5148393 | 0.86 | HTT (0.39) | ALDH1A1LMNAHTTTSHRMAPK1 | |
| SCHEMBL2975235 | 0.85 | MERTK (0.34) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |