Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145889 | 0.93 | ALDH1A1 (0.35) | CYP2A6ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5147380 | 0.90 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147313 | 0.87 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5148362 | 0.87 | CDK2 (0.39) | CYP2A6TGFBR1MAPK14CDK2CLK1 | |
| SCHEMBL5148335 | 0.86 | PDE3B (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL2986566 | 0.85 | CYP2A6 (0.34) | CYP2A6TGFBR1MAPK14HDAC3HDAC1 | |
| SCHEMBL5147302 | 0.85 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147498 | 0.85 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5149101 | 0.83 | RAF1 (0.37) | TGFBR1MAPK14 | |
| SCHEMBL5147318 | 0.83 | GAA (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |