Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3072007 | 0.72 | KDM4E (0.48) | KDM4EKMT2ALMNANCF1MAPK1 | |
| SCHEMBL3070822 | 0.69 | KDM4E (0.48) | KDM4EKMT2ALMNANCF1MAPK1 | |
| SCHEMBL11947996 | 0.62 | L3MBTL1 (0.45) | KDM4ENCF1MAPK1 | |
| SCHEMBL3059495 | 0.61 | KDM4E (0.48) | KDM4EKMT2ALMNANCF1MAPK1 | |
| SCHEMBL3059462 | 0.58 | NCF1 (0.48) | KDM4EKMT2ALMNANCF1KCNH2 | |
| SCHEMBL27595365 | 0.58 | KDM4E (0.49) | KDM4EKMT2ALMNANCF1KCNH2 | |
| SCHEMBL1223373 | 0.57 | NCF1 (0.64) | KDM4EKMT2ALMNANCF1KCNH2 | |
| SCHEMBL23112084 | 0.57 | STING1 (0.72) | STING1 | |
| SCHEMBL4600323 | 0.57 | KDM4E (1.00) | KDM4ELMNAMAPK1NPSR1 | |
| SCHEMBL3066905 | 0.56 | NCF1 (0.48) | KDM4EKMT2ALMNANCF1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863483-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006105289-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |