Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | C1S | P09871 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163949 | 0.82 | PARP1 (1.00) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL16803128 | 0.82 | PARP1 (1.00) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL241785 | 0.81 | PARP1 (0.68) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL30153175 | 0.81 | PARP1 (0.68) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL6670439 | 0.81 | PARP1 (0.68) | PARP1ALDH1A1TP53C1SHPGD | |
| Hydrochloric Acid SCHEMBL4376137 | 0.80 | PARP1 (0.96) | PARP1ALDH1A1TP53C1SHPGD | |
| Hydrochloric Acid SCHEMBL5319538 | 0.80 | PARP1 (0.96) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL180430 | 0.79 | PARP1 (0.65) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL8681033 | 0.79 | PARP1 (0.65) | PARP1ALDH1A1TP53C1SHPGD | |
| SCHEMBL5023 | 0.79 | PARP1 (0.65) | PARP1ALDH1A1TP53C1SHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053847-B | 17 β -imidazolidinyl bromide-dehydroepiandrostane derivative and preparation method and application thereof | 云南大学 | 2020-05-19 | — | — | CN | claimed |
| WO-2023210623-A1 | HALOALKYL SULFONE ANILIDE COMPOUND AND HERBICIDE CONTAINING SAME | 株式会社エス・ディー・エス バイオテック | 2023-11-02 | — | — | WO | disclosed |
| EP-3313832-B1 | 3-TETRAZOLYL-BENZENE-1,2-DISULFONAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-02-24 | — | — | EP | disclosed |
| CN-109053847-B | 17 β -imidazolidinyl bromide-dehydroepiandrostane derivative and preparation method and application thereof | 云南大学 | 2020-05-19 | — | — | CN | disclosed |
| US-10544130-B2 | Metallo-beta-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190144432-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-05-16 | — | — | US | disclosed |
| US-10221163-B2 | Metallo-beta-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20180244656-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-08-30 | — | — | US | disclosed |
| EP-3313832-A1 | 3-TETRAZOLYL-BENZENE-1,2-DISULFONAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016210215-A1 | 3-TETRAZOLYL-BENZENE-1,2-DISULFONAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-29 | — | — | WO | disclosed |
| US-4451481-A | ANTICHOLESTEROL AGENTS | SANKYO COMPANY LIMITED (JP) | 1984-05-29 | — | — | US | disclosed |
| US-4447626-A | TREATMENT OF HYPERCHOLESTEROLEMIA | SANKYO COMPANY LIMITED (JP) | 1984-05-08 | — | — | US | disclosed |
| US-4438277-A | Hydronaphthalene derivatives | SANKYO COMPANY, LIMITED (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0076601-A1 | Octahydronaphthalene derivatives and their preparation | SANKYO COMPANY LIMITED (JP) | 1983-04-13 | — | — | EP | disclosed |
| EP-0074222-A1 | MB-530B derivatives, their preparation and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1983-03-16 | — | — | EP | disclosed |
| EP-0070649-A2 | ML-236B Derivatives, a process for their preparation and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1983-01-26 | — | — | EP | disclosed |
| EP-0065835-A1 | M-4 and iso M-4 derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-01 | — | — | EP | disclosed |
| EP-0065843-A1 | New M-4 and iso M-4 derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-01 | — | — | EP | disclosed |
| US-4361515-A | Antihyperlipemic dihydro-ML-236B derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1982-11-30 | — | — | US | disclosed |
| US-4137322-A | ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents | SANKYO COMPANY LIMITED (JP) | 1979-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544130-B2 | Metallo-beta-lactamase inhibitors | MLX, ZFX, MMP12 | PARP1 1761/4885ALDH1A1 277/4885TP53 4403/4885 |
| US-10221163-B2 | Metallo-beta-lactamase inhibitors | MLX, ZFX, MMP12 | PARP1 1810/4885ALDH1A1 259/4885TP53 4474/4885 |
| US-20190144432-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MLX, ZFX, MMP12 | PARP1 1761/4885ALDH1A1 277/4885TP53 4403/4885 |
| US-20180244656-A1 | METALLO-BETA-LACTAMASE INHIBITORS | MLX, ZFX, MMP12 | PARP1 1810/4885ALDH1A1 259/4885TP53 4474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.