Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29128742 | 0.83 | CES2 (0.66) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL30725444 | 0.83 | CES2 (0.66) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL8026060 | 0.82 | CES2 (0.56) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL8026063 | 0.82 | CES2 (0.56) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL10925104 | 0.82 | CYP3A4 (0.57) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL31388927 | 0.81 | CES2 (0.59) | CES2CES1TP53ALDH1A1TSHR | |
| Water SCHEMBL28303785 | 0.80 | TP53 (0.96) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL6607552 | 0.80 | ALDH1A1 (0.67) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL31374765 | 0.80 | CES1 (1.00) | CES2CES1TP53ALDH1A1TSHR | |
| SCHEMBL181572 | 0.80 | CES2 (0.78) | CES2CES1TP53ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451162-A4 | SUBSTITUTED DIPHENYL HETEROCYCLES USEFUL FOR TREATING HCV INFECTION | RIGEL PHARMACEUTICALS INC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-7153880-B2 | Substituted diphenyl heterocycles useful for treating HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-26 | — | — | US | disclosed |
| US-7115642-B2 | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection | RIGEL PHARMACEUTICALS, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20040266840-A1 | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection | MIDCAP FINANCIAL TRUST | 2004-12-30 | — | — | US | disclosed |
| US-20040236112-A1 | Substituted diphenyl heterocycles useful for treating HCV infection | MIDCAP FINANCIAL TRUST | 2004-11-25 | — | — | US | disclosed |
| WO-2004099164-A1 | SUBSTITUTED DIPHENYL ISOXAZOLES, PYRAZOLES AND OXADIAZOLES USEFUL FOR TREATING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-1451162-A1 | SUBSTITUTED DIPHENYL HETEROCYCLES USEFUL FOR TREATING HCV INFECTION | Rigel Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| US-6759538-B2 | PREVENTION INFECTIONS OF HEPATITIS C VIRUS | RIGEL PHARMACEUTICALS, INC. | 2004-07-06 | — | — | US | disclosed |
| US-20030165561-A1 | Substituted diphenyl heterocycles useful for treating HCV infection | MIDCAP FINANCIAL TRUST | 2003-09-04 | — | — | US | disclosed |
| WO-2003040112-A1 | SUBSTITUTED DIPHENYL HETEROCYCLES USEFUL FOR TREATING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | disclosed |
| US-4228082-A | FUNGICIDES OR CHEMICAL INTERMIDIATES FOR 1,2,4-TRIAZINONE HERBICIDES | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1980-10-14 | — | — | US | disclosed |
| US-4224226-A | FUNGICIDES BY CONDENSING AN ACYL CYANIDE WITH EITHER A TERTIARY ALCOHOL OR AN ALKENE | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1980-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266840-A1 | Substituted diphenyl isoxazoles, pyrazoles and oxadiazoles useful for treating HCV infection | HAVCR2, MAVS, RPL35 | CES2 2713/4885CES1 774/4885TP53 1208/4885 |
| US-20040236112-A1 | Substituted diphenyl heterocycles useful for treating HCV infection | HAVCR2, HCCS, PCNA | CES2 1333/4885CES1 1082/4885TP53 383/4885 |
| US-20030165561-A1 | Substituted diphenyl heterocycles useful for treating HCV infection | HAVCR2, HCCS, PCNA | CES2 1333/4885CES1 1082/4885TP53 383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.