Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 2/20 | 1.00 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.80 |
| ▸ | USP2 | O75604 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | CASP7 | P55210 | 3/20 | 0.77 |
| ▸ | TP53 | P04637 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | BLM | P54132 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | MDM4 | O15151 | 1/20 | 0.77 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.77 |
| ▸ | VDR | P11473 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lagodeoxycholate SCHEMBL12998476 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL11967213 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL22415902 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL22415770 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL24001452 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL24032585 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL24124431 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL23781732 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL22778334 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R | |
| Lagodeoxycholate SCHEMBL12575822 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4PDE3ASLC10A2TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55153799-A | — | — | None | — | — | JP | disclosed |
| US-20220009957-A1 | Methods for Preparing Bile Acids | MEDYTOX INC. (KR) | 2022-01-13 | — | — | US | disclosed |
| EP-3251654-A1 | NONIONIC SURFACTANTS FOR REDUCTION OF ADIPOSE TISSUE | CHEMISCHE FABRIK KREUSSLER & CO. GMBH (DE) | 2017-12-06 | — | — | EP | disclosed |
| EP-3002290-A2 | SYNTHESIS OF DEOXYCHOLIC ACID (DCA) | Kythera Biopharmaceuticals, Inc. (US) | 2016-04-06 | — | — | EP | disclosed |
| EP-1751145-A4 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | CHONG KUN DANG PHARM CORP (KR) | 2007-08-01 | — | — | EP | disclosed |
| US-7229980-B2 | Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or derivative thereof | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2007-06-12 | — | — | US | disclosed |
| EP-1751145-A1 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | Chong Kun Dang Pharmaceutical Corp. (KR) | 2007-02-14 | — | — | EP | disclosed |
| WO-2006033505-A1 | PAROXETINE CHOLATE OR CHOLIC ACID DERIVATIVE SALTS, AND COMPOSITION COMPRISING PAROXETINE AND CHOLIC ACID OR CHOLIC ACID DERIVATIVES | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2006-03-30 | — | — | WO | disclosed |
| US-20060063747-A1 | Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or derivative thereof | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2006-03-23 | — | — | US | disclosed |
| US-6274118-B1 | INJECTING PATIENT HAVING ENDOCRINE CANCER IN NON-PROSTATIC TISSUE WITH BIOLOGICAL BINDING UNITS WHICH BIND TO PROSTATE SPECIFIC ANTIGEN PRODUCED BY NON-PROSTATIC TISSUE | NORDION INTERNATIONAL INC. (CA) | 2001-08-14 | — | — | US | disclosed |
| US-4277408-A | Novel purification process | ROUSSEL UCLAF (FR) | 1981-07-07 | — | — | US | disclosed |
| JP-S55153799-A | PREPARATION OF 3ALPHA-HYDROXY-KETO-CHOLANIC ACID | AMANO PHARMACEUT CO LTD | 1980-11-29 | — | — | JP | disclosed |
| US-4104285-A | OF NORCHOLANIC ACID, BISNORCHOLANIC ACID, OR ETIOCHOLANIC ACID, STEROIDS, BILE FLOW STIMULATORS, ANTILIPEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1978-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063747-A1 | Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or derivative thereof | SLC10A2, SLC10A1, CYP3A5 | GPBAR1 269/4885NR1H4 19/4885PDE3A 405/4885 |
| US-20220009957-A1 | Methods for Preparing Bile Acids | DHCR7, CYP46A1, CYP27A1 | GPBAR1 55/4885NR1H4 27/4885PDE3A 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.