Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2050725 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL515643 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL541628 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL2048861 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL542243 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL514845 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL3493992 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL28883791 | 1.00 | SLC18A3 (0.44) | SLC18A3NAAANPC1LMNATP53 | |
| SCHEMBL27967862 | 0.92 | NAAA (0.46) | NAAANPC1LMNATP53HPGD | |
| SCHEMBL27967864 | 0.92 | NAAA (0.46) | NAAANPC1LMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107228909-B | Method for measuring acotiamide hydrochloride raw material medicine and related substances in preparation thereof by using HPLC | 中美华世通生物医药科技(武汉)股份有限公司 | 2021-05-28 | — | — | CN | claimed |
| WO-2015039675-A1 | NOVEL PROCESS FOR THE PREPARATION OF EZETIMIBE INTERMEDIATES | PHARMATHEN S.A. (GR) | 2015-03-26 | — | — | WO | claimed |
| EP-2329014-B1 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE | CODEXIS INC (US) | 2014-10-22 | — | — | EP | claimed |
| EP-2414339-B1 | KINETIC RESOLUTION OF (4S)-4-PHENYL-3-[5(RS)-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-1,3 OXAZOLIDIN 2-ONE TO (5S) ISOMER VIA LIPASE CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF THE (5R) ISOMER | LUPIN LTD (IN) | 2013-01-16 | — | — | EP | claimed |
| US-8273554-B2 | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one | CODEXIS, INC. (US) | 2012-09-25 | — | — | US | claimed |
| EP-2414339-A1 | KINETIC RESOLUTION OF (4S)-4-PHENYL-3-Ý5(RS)-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL¨-1,3 OXAZOLIDIN 2-ONE TO (5S) ISOMER VIA LIPASE CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF THE (5R) ISOMER | Lupin Ltd. (IN) | 2012-02-08 | — | — | EP | claimed |
| US-20120028340-A1 | KINETIC RESOLUTION OF (4S) -- 4- PHENYL -- 3- [(5RS)-5-(4-FLUROPHENYL)-5- HYDROXYPENTANOYL] --1,3-OXAZOLIDIN-2-ONE TO THE (5S) ISOMER VIA LIPASE CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF THE (5R) ISOMER | LUPIN LIMITED (IN) | 2012-02-02 | — | — | US | claimed |
| EP-2329014-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3Ý(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL¨-4-PHENYL-1,3-OXAZOLIDIN-2-ONE | Codexis, Inc. (US) | 2011-06-08 | — | — | EP | claimed |
| WO-2010113184-A1 | KINETIC RESOLUTION OF (4S)-4-PHENYL-3-[5(RS)-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL] -1,3 OXAZOLIDIN 2-ONE TO (5S) ISOMER VIA LIPASE CATALYZED ENANTIOSELECTIVE ESTERIFICATION OF THE (5R) ISOMER | LUPIN LIMITED (IN) | 2010-10-07 | — | — | WO | claimed |
| US-20100062499-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE | CODEXIS, INC. (US) | 2010-03-11 | — | — | US | claimed |
| WO-2010025085-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3[(5S)-5(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE | CODEXIS, INC. (US) | 2010-03-04 | — | — | WO | claimed |
| US-12365881-B2 | Ketoreductase polypeptides | CODEXIS, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| US-12365881-B2 | Ketoreductase polypeptides | CODEXIS, INC. (US) | 2025-07-22 | — | — | US | disclosed |
| US-20250011733-A1 | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | CODEXIS INC (US) | 2025-01-09 | — | — | US | disclosed |
| US-12110512-B2 | Biocatalysts for ezetimibe synthesis | CODEXIS, INC. (US) | 2024-10-08 | — | — | US | disclosed |
| EP-1893571-A2 | PROCESS FOR PRODUCTION OF 4-BIPHENYLYAZETIDIN-2-ONES | Microbia Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1885703-A2 | PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES | Microbia, Inc. (US) | 2008-02-13 | — | — | EP | disclosed |
| US-20070135357-A1 | Anti-hypercholesterolemic compounds | MERCK & CO., INC. | 2007-06-14 | — | — | US | disclosed |
| WO-2006122020-A2 | PROCESS FOR PRODUCTION OF 4-BIPHENYLYAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006122216-A2 | PROCESSES FOR PRODUCTION OF PHENOLIC 4-BIPHENYLYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135357-A1 | Anti-hypercholesterolemic compounds | NPC1L1, PCSK9, CETP | SLC18A3 2440/4885NAAA 1766/4885NPC1 6/4885 |
| US-12110512-B2 | Biocatalysts for ezetimibe synthesis | APOB, PCSK9, CETP | SLC18A3 2066/4885NAAA 486/4885NPC1 99/4885 |
| US-20250011733-A1 | BIOCATALYSTS FOR EZETIMIBE SYNTHESIS | APOB, PCSK9, CETP | SLC18A3 2066/4885NAAA 486/4885NPC1 99/4885 |
| US-20100062499-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE STEREOSELECTIVE PRODUCTION OF (4S)-3-[(5S)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE | DPYD, DHFR, AKR1B1 | SLC18A3 4259/4885NAAA 2501/4885NPC1 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.