Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ARNT | P27540 | 3/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322420 | 0.81 | PTGER4 (0.45) | PTGER4HCAR3MAPTLMNAALDH1A1 | |
| SCHEMBL18322365 | 0.78 | KAT2B (0.44) | PTGER4HCAR3MAPTLMNAARNT | |
| SCHEMBL18322408 | 0.75 | PTGER4 (0.66) | PTGER4HCAR3MAPTLMNAPGK1 | |
| SCHEMBL3146630 | 0.74 | KAT2B (0.50) | HCAR3MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL982086 | 0.74 | KAT2B (0.48) | HCAR3MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL11303709 | 0.72 | ALDH1A1 (0.48) | MAPTLMNAARNTEPAS1VCAM1 | |
| SCHEMBL30391374 | 0.72 | ALDH1A1 (0.42) | HCAR3MAPTLMNAARNTEPAS1 | |
| SCHEMBL28182819 | 0.71 | MEN1 (0.56) | MAPTVCAM1ALDH1A1MEN1KMT2A | |
| SCHEMBL30263678 | 0.71 | HCAR3 (0.38) | HCAR3MAPTLMNAPGK1ALDH1A1 | |
| SCHEMBL8097768 | 0.70 | HCAR3 (0.49) | HCAR3MAPTLMNAPGK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1617807-A4 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | ORTHO MCNEIL PHARM INC (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1617807-A2 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | Ortho-McNeil Pharmaceuticals, Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004096134-A2 | SUBSTITUTED 1,4-DIAZEPINES AND USES THEREOF | ORTHO-MCNEIL PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |