Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458027 | 0.89 | TP53 (0.74) | TP53ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14428687 | 0.85 | KMT2A (0.70) | TP53ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14428692 | 0.80 | ALDH1A1 (0.56) | TP53ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14440389 | 0.79 | ALDH1A1 (0.57) | TP53ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL647000 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNASMN1; SMN2NPSR1 | |
| SCHEMBL12870002 | 0.67 | USP2 (0.70) | ALDH1A1LMNASMN1; SMN2NPSR1HTT | |
| SCHEMBL13091058 | 0.67 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL3874256 | 0.66 | CYP2C9 (0.57) | TP53ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL21843160 | 0.66 | ACP1 (0.70) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL5474202 | 0.66 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740176-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-INFLAMMATORY QUINAZOLINECARBOXAMIDE DERIVATIVES | Rimonyx Pharmaceuticals Ltd. (IL) | 2007-01-10 | — | — | EP | claimed |
| WO-2005089068-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING ANTI-INFLAMMATORY QUINAZOLINECARBOXAMIDE DERIVATIVES | RIMONYX PHARMACEUTICALS LTD. (IL) | 2005-09-29 | — | — | WO | claimed |
| US-20070191400-A1 | Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives | RIMONYX PHARMACEUTICALS LTD. (IL) | 2007-08-16 | — | — | US | disclosed |
| US-20070191400-A1 | Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives | RIMONYX PHARMACEUTICALS LTD. (IL) | 2007-08-16 | — | — | US | disclosed |
| US-20070191400-A1 | Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives | RIMONYX PHARMACEUTICALS LTD. (IL) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191400-A1 | Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives | HPSE, SSB, HCLS1 | TP53 802/4885ALDH1A1 2758/4885KDM4E 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.