Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 6/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 6/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 6/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 6/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.38 |
| ▸ | CACNB3 | P54284 | 6/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.38 |
| ▸ | CACNG7 | P62955 | 6/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 6/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 6/20 | 0.38 |
| ▸ | CACNG1 | Q06432 | 6/20 | 0.38 |
| ▸ | CACNB2 | Q08289 | 6/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148944 | 0.90 | FABP4 (0.43) | FABP3FABP4MEN1KMT2AFFAR4 | |
| SCHEMBL5147735 | 0.87 | CACNB4 (0.39) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL5148724 | 0.86 | BCL2 (0.45) | FABP3FABP4MEN1KMT2APIK3CA | |
| SCHEMBL5148898 | 0.85 | FABP4 (0.41) | CACNA1BFABP3FABP4FFAR4FAAH | |
| SCHEMBL5151982 | 0.84 | MDM2 (0.41) | FABP3FABP4PIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL5150749 | 0.84 | CACNB4 (0.39) | PDE4DCACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL5171475 | 0.83 | RPA1 (0.42) | FABP3FABP4FFAR4PIK3CAPIK3CG | |
| SCHEMBL5148760 | 0.83 | FABP3 (0.39) | FABP3FABP4PIK3CAPIK3CG | |
| SCHEMBL5148783 | 0.83 | PTGS2 (0.41) | CACNA1GCACNA1HFABP3FABP4PIK3CA | |
| SCHEMBL5148880 | 0.83 | MDM2 (0.41) | FABP3FABP4PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567503-B1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | ASTELLAS PHARMA INC (JP) | 2011-12-21 | — | — | EP | disclosed |
| US-20070112037-A1 | Pyrazole Derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-7183306-B2 | Pyrazole derivatives | ASTELLAS PHARMA INC. (JP) | 2007-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112037-A1 | Pyrazole Derivatives | CYP11B2, CYP11B1, CYP3A43 | PDE4A 3389/4885PDE4B 2995/4885PDE4C 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.