Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.56 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5155250 | 0.90 | PDE4B (0.44) | PDE4BMELKCHEK1CHEK2 | |
| SCHEMBL5158265 | 0.77 | PDE4B (0.58) | PDE4B | |
| SCHEMBL2773376 | 0.73 | PDE4B (1.00) | PDE4BCHEK1CHEK2 | |
| SCHEMBL5962970 | 0.73 | PDE4B (0.64) | PDE4B | |
| SCHEMBL8342425 | 0.71 | PDE4B (0.70) | PDE4B | |
| SCHEMBL3428110 | 0.70 | PDE4B (0.69) | PDE4B | |
| SCHEMBL13870222 | 0.69 | PDE4B (0.62) | PDE4B | |
| SCHEMBL4937907 | 0.68 | PDE4B (0.64) | PDE4B | |
| SCHEMBL4934777 | 0.68 | PDE4B (0.64) | PDE4B | |
| SCHEMBL4934822 | 0.68 | PDE4B (0.64) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007514704-A | — | — | 2007-06-07 | — | — | JP | claimed |
| EP-1737857-A1 | PYRAZOLO[3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-01-03 | — | — | EP | claimed |
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | claimed |