Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5473640 | 0.79 | PDE4B (0.44) | PDE4BJAK2JAK1TYK2JAK3 | |
| SCHEMBL5154835 | 0.77 | PDE4B (0.56) | PDE4B | |
| SCHEMBL5962970 | 0.75 | PDE4B (0.64) | PDE4B | |
| SCHEMBL8342425 | 0.74 | PDE4B (0.70) | PDE4BKCNH2 | |
| SCHEMBL2773376 | 0.74 | PDE4B (1.00) | PDE4BJAK1JAK3 | |
| SCHEMBL3428110 | 0.73 | PDE4B (0.69) | PDE4BKCNH2JAK2JAK1TYK2 | |
| SCHEMBL5962805 | 0.72 | PDE4B (0.54) | PDE4BKCNH2JAK2JAK1TYK2 | |
| SCHEMBL4345860 | 0.70 | PDE4B (0.68) | PDE4B | |
| SCHEMBL4336764 | 0.70 | PDE4B (0.54) | PDE4BKCNH2 | |
| SCHEMBL5962845 | 0.68 | PDE4B (0.54) | PDE4BJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737857-A1 | PYRAZOLO[3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005058892-A1 | PYRAZOLO [3,4-B] PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-06-30 | — | — | WO | disclosed |