Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1832370 | 1.00 | GSR (0.45) | GSRCPB2RNPEPALDH1A1ENPEP | |
| Bicarbonate SCHEMBL1829915 | 1.00 | GSR (0.45) | GSRCPB2RNPEPALDH1A1ENPEP | |
| Oxalic Acid SCHEMBL1830899 | 0.93 | GSR (0.43) | GSRCPB2RNPEPALDH1A1ENPEP | |
| Acetic Acid SCHEMBL1833072 | 0.91 | GSR (0.42) | GSRCPB2RNPEPALDH1A1ENPEP | |
| Glycolic Acid SCHEMBL1839847 | 0.91 | GSR (0.42) | GSRCPB2RNPEPALDH1A1ENPEP | |
| SCHEMBL1832529 | 0.91 | ALDH1A1 (0.37) | GSRCPB2RNPEPALDH1A1ENPEP | |
| Succinic Acid SCHEMBL1838797 | 0.90 | LMNA (0.48) | GSRALDH1A1ENPEPLMNATHRB | |
| Bromide SCHEMBL1831768 | 0.88 | ALDH1A1 (0.35) | GSRCPB2ALDH1A1TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL1831383 | 0.88 | ALDH1A1 (0.35) | GSRCPB2ALDH1A1TSHRNFKB1 | |
| Iodide SCHEMBL1835199 | 0.88 | ALDH1A1 (0.35) | GSRCPB2ALDH1A1TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948589-A1 | IONIC LIQUIDS | Bioniqs Limited (GB) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007036712-A1 | IONIC LIQUIDS | BIONIQS LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |