Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 18/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14558830 | 0.93 | ITGA4 (0.52) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL5152912 | 0.88 | ITGA4 (0.51) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL5155094 | 0.86 | ITGA4 (0.44) | ITGA4ITGB1ALDH1A1 | |
| SCHEMBL14558358 | 0.84 | ITGA4 (0.55) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL14558359 | 0.83 | ITGA4 (0.50) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL5152022 | 0.83 | ITGA4 (0.50) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL14558349 | 0.82 | ITGA4 (0.57) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL5149771 | 0.82 | ITGA4 (0.57) | ITGA4ITGB1ALDH1A1PYGL | |
| SCHEMBL14558365 | 0.81 | ITGA4 (0.57) | ITGA4ITGB1ALDH1A1 | |
| SCHEMBL14569670 | 0.79 | ITGA4 (0.56) | ITGA4ITGB1ALDH1A1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054909-A1 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | US | disclosed |
| US-7179819-B2 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2007-02-20 | — | — | US | disclosed |
| US-20040229858-A1 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-11-18 | — | — | US | disclosed |
| US-6756378-B2 | BENZYL -UREA, -THIOUREA, OR -GUANIDINE DERIVATIVES THAT INHIBIT THE BINDING OF LIGANDS TO ALPHA 4 BETA 1 INTEGRIN (VLA-4) | PHARMACOPEIA DRUG DISCOVERY, INC. | 2004-06-29 | — | — | US | disclosed |
| US-20030078249-A1 | VLA-4 inhibitor compounds | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078249-A1 | VLA-4 inhibitor compounds | VCAM1, ICAM1, ITGA4 | ITGA4 3/4885ITGB1 7/4885ALDH1A1 146/4885 |
| US-20070054909-A1 | VLA-4 inhibitor compounds | VCAM1, ITGB4, ICAM1 | ITGA4 4/4885ITGB1 8/4885ALDH1A1 120/4885 |
| US-20040229858-A1 | VLA-4 inhibitor compounds | VCAM1, ICAM1, ITGB4 | ITGA4 5/4885ITGB1 7/4885ALDH1A1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.