Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | FABP1 | P07148 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.35 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3859945 | 0.92 | PLA2G2A (0.54) | PLA2G2AKMT2ANR1H4DRD2RAB9A | |
| SCHEMBL3858281 | 0.87 | PLA2G2A (0.59) | PLA2G2AKMT2ANR1H4MAPTRAB9A | |
| SCHEMBL5158669 | 0.84 | LMNA (0.39) | PLA2G2AKMT2AMAPTLMNAKDM4E | |
| SCHEMBL19999965 | 0.81 | MAPT (0.55) | PLA2G2AKMT2ANR1H4MAPTRAB9A | |
| SCHEMBL5156755 | 0.81 | MEN1 (0.39) | KMT2AMAPTRAB9ALMNAKDM4E | |
| SCHEMBL4373510 | 0.81 | LMNA (0.36) | PLA2G2AKMT2AMAPTLMNAKDM4E | |
| SCHEMBL2772131 | 0.80 | PLA2G2A (0.67) | PLA2G2AKMT2ANR1H4MAPTRAB9A | |
| SCHEMBL3854271 | 0.80 | HCAR3 (0.44) | PLA2G2AKMT2ARAB9A | |
| SCHEMBL3854874 | 0.79 | NOTUM (0.48) | KMT2AMAPTLMNAKDM4E | |
| SCHEMBL3886309 | 0.79 | LMNA (0.43) | KMT2AMAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |