Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654028 | 0.81 | PFKFB3 (0.38) | PFKFB3PFKFB4MAPTTBXAS1TP53 | |
| SCHEMBL4655093 | 0.78 | ALDH1A1 (0.40) | MAPTL3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4655071 | 0.72 | MAPT (0.36) | PFKFB3PFKFB4MAPTTBXAS1ALDH1A1 | |
| SCHEMBL4655072 | 0.71 | LMNA (0.38) | MAPTALDH1A1TP53SMN1; SMN2KDM4E | |
| SCHEMBL4654001 | 0.70 | PIM1 (0.34) | PFKFB3PFKFB4MAPTTBXAS1L3MBTL1 | |
| SCHEMBL10947088 | 0.67 | KMT2A (0.50) | PFKFB3PFKFB4MAPTDHODHTSHR | |
| SCHEMBL25946676 | 0.64 | SMN1; SMN2 (0.45) | MAPTTSHRL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2896475 | 0.64 | GPR35 (0.58) | PFKFB3PFKFB4TBXAS1ALDH1A1TP53 | |
| SCHEMBL5094416 | 0.64 | PFKFB3 (0.43) | PFKFB3PFKFB4MAPTTBXAS1ALDH1A1 | |
| SCHEMBL10958206 | 0.64 | PFKFB3 (0.54) | PFKFB3PFKFB4MAPTTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740568-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE. | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005077926-A2 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |