Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 3/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.41 |
| ▸ | PRKACA | P17612 | 3/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760768 | 0.84 | ALDH1A1 (0.65) | NPC1ALDH1A1LMNACYP1A2CLCN2 | |
| SCHEMBL30499673 | 0.84 | ALDH1A1 (0.65) | NPC1ALDH1A1LMNACYP1A2CLCN2 | |
| SCHEMBL11093462 | 0.81 | CYP1A2 (0.40) | NPC1ALDH1A1LMNACDC7PLK4 | |
| SCHEMBL1439894 | 0.80 | TYK2 (0.52) | NPC1LMNACYP1A2KDM4EMEN1 | |
| SCHEMBL5519442 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1CYP1A2PEPDKDM4E | |
| SCHEMBL11877504 | 0.78 | LMNA (0.37) | ALDH1A1LMNACDC7PLK4DYRK3 | |
| SCHEMBL11426891 | 0.77 | NPC1 (0.41) | NPC1ALDH1A1LMNACYP1A2PEPD | |
| SCHEMBL4201824 | 0.77 | LMNA (0.47) | NPC1ALDH1A1LMNACYP1A2PEPD | |
| Oxalic Acid SCHEMBL20984292 | 0.72 | ALDH1A1 (0.43) | NPC1ALDH1A1LMNACYP1A2CLCN2 | |
| SCHEMBL8766073 | 0.72 | ALDH1A1 (0.44) | ALDH1A1LMNACDC7PLK4DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737830-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | The Procter and Gamble Company (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005105757-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-10 | — | — | WO | disclosed |