Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.39 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986952 | 0.85 | MEN1 (0.47) | ATF4MEN1KMT2ALMNARAB9A | |
| SCHEMBL2976705 | 0.83 | MEN1 (0.52) | MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2987483 | 0.81 | ATF4 (0.61) | ATF4POLBMEN1KMT2AUSP2 | |
| SCHEMBL2978761 | 0.80 | ATF4 (0.65) | ATF4POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2987110 | 0.79 | MEN1 (0.51) | POLBMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2987816 | 0.77 | MEN1 (0.47) | MEN1KMT2ALMNARAB9A | |
| SCHEMBL5159146 | 0.77 | MEN1 (0.45) | POLBMEN1KMT2AHRH3LMNA | |
| SCHEMBL2977860 | 0.77 | ATF4 (0.60) | ATF4POLBMEN1KMT2ALMNA | |
| SCHEMBL2985500 | 0.76 | ATF4 (0.57) | ATF4POLBMEN1KMT2AUSP2 | |
| SCHEMBL2982759 | 0.76 | ATF4 (0.57) | ATF4POLBMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536322-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | claimed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |