Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2972836 | 0.83 | MEN1 (0.50) | MEN1KMT2APOLBRAB9AMAPT | |
| SCHEMBL2981453 | 0.80 | RAB9A (0.39) | MEN1KMT2APOLBRAB9ANPC1 | |
| SCHEMBL2985450 | 0.79 | OPRM1 (0.47) | MEN1KMT2APOLBEPHX2HPGD | |
| SCHEMBL2987110 | 0.79 | MEN1 (0.51) | MEN1KMT2APOLBRAB9AMAPT | |
| SCHEMBL5155945 | 0.77 | ATF4 (0.42) | MEN1KMT2APOLBRAB9AHRH3 | |
| SCHEMBL2985459 | 0.77 | POLB (0.59) | MEN1KMT2APOLBRAB9ALMNA | |
| SCHEMBL2983320 | 0.77 | POLB (0.59) | MEN1KMT2APOLBRAB9ALMNA | |
| SCHEMBL2987472 | 0.76 | NPSR1 (0.48) | MEN1KMT2APOLBRAB9AMAPT | |
| SCHEMBL2985703 | 0.76 | MEN1 (0.59) | MEN1KMT2ARAB9AMAPTNPC1 | |
| SCHEMBL2986952 | 0.75 | MEN1 (0.47) | MEN1KMT2ARAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007536322-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | claimed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |