Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977860 | 0.96 | ATF4 (0.60) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2987483 | 0.95 | ATF4 (0.61) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2987178 | 0.90 | ATF4 (0.58) | ATF4KMT2ALMNAPOLB | |
| SCHEMBL2981298 | 0.88 | ATF4 (0.56) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2972810 | 0.87 | ATF4 (0.55) | ATF4KMT2ALMNAPOLB | |
| SCHEMBL2985870 | 0.86 | ATF4 (0.59) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2989096 | 0.86 | ATF4 (0.58) | ATF4KMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL2981361 | 0.85 | ATF4 (0.57) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2972824 | 0.84 | ATF4 (0.59) | ATF4KMT2ALMNAMEN1POLB | |
| SCHEMBL2983764 | 0.84 | LMNA (0.58) | ATF4KMT2ALMNAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | claimed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | claimed |
| US-7786328-B2 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-12-06 | — | — | US | disclosed |
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281954-A1 | Cyclohexyl-1,4-diamine compounds | DPYD, PKD1, AOC1 | ATF4 1845/4885KMT2A 3786/4885LMNA 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.