Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | AHCY | P23526 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156197 | 0.98 | LMNA (0.36) | KDM1AATMAHCYGPR119TRPV1 | |
| SCHEMBL475536 | 0.87 | KLK7 (0.38) | KDM1AAHCYGPR119NPSR1OPRD1 | |
| SCHEMBL4363998 | 0.81 | CCR3 (0.35) | KDM1AGPR119LMNANPSR1MEN1 | |
| SCHEMBL4363997 | 0.81 | CCR3 (0.35) | KDM1AGPR119LMNANPSR1MEN1 | |
| SCHEMBL4364638 | 0.81 | CCR3 (0.35) | KDM1AGPR119LMNANPSR1MEN1 | |
| SCHEMBL5156033 | 0.80 | KDM1A (0.42) | KDM1AATMOPRD1MEN1KMT2A | |
| SCHEMBL5159359 | 0.80 | KDM1A (0.42) | KDM1AATMOPRD1MEN1KMT2A | |
| SCHEMBL3854142 | 0.78 | DPP4 (0.36) | GPR119LMNANPSR1MEN1KMT2A | |
| SCHEMBL3854146 | 0.78 | DPP4 (0.36) | GPR119LMNANPSR1MEN1KMT2A | |
| SCHEMBL5159070 | 0.78 | PDE8B (0.40) | KDM1AATMTRPV1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |