Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156033 | 1.00 | KDM1A (0.42) | KDM1AJAK2JAK1PRMT5MEN1 | |
| SCHEMBL5153000 | 0.97 | OPRD1 (0.42) | KDM1AJAK2JAK1PRMT5MEN1 | |
| SCHEMBL475536 | 0.88 | KLK7 (0.38) | KDM1AJAK2JAK1PRMT5MEN1 | |
| SCHEMBL5159126 | 0.84 | AGTR2 (0.42) | JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL5155901 | 0.84 | CETP (0.41) | JAK2JAK1KMT2AL3MBTL1 | |
| SCHEMBL5158541 | 0.80 | JAK2 (0.38) | JAK2JAK1ATMOPRD1 | |
| SCHEMBL5156143 | 0.80 | KDM1A (0.37) | KDM1APRMT5MEN1KMT2AATM | |
| SCHEMBL5157337 | 0.80 | JAK2 (0.38) | JAK2JAK1ATMNR1H2NR1H3 | |
| SCHEMBL21216253 | 0.79 | KDM1A (0.42) | KDM1AJAK2JAK1PRMT5ATM | |
| SCHEMBL21202236 | 0.79 | KDM1A (0.42) | KDM1AJAK2JAK1PRMT5ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |