Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5153000 | 0.91 | OPRD1 (0.42) | KLK7JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL5156197 | 0.89 | LMNA (0.36) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL5159359 | 0.88 | KDM1A (0.42) | KLK7JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL5156033 | 0.88 | KDM1A (0.42) | KLK7JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL5156143 | 0.87 | KDM1A (0.37) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL11970385 | 0.80 | KLK7 (0.41) | KLK7JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL11970386 | 0.80 | KLK7 (0.41) | KLK7JAK2JAK1NR1H2NR1H3 | |
| SCHEMBL5155797 | 0.80 | ALOX5AP (0.42) | APPHTR1AADRA2ADRD2ADRA2B | |
| SCHEMBL5311579 | 0.78 | LMNA (0.34) | NR1H2NR1H3MAPTNPSR1GPR119 | |
| SCHEMBL5311580 | 0.78 | LMNA (0.34) | NR1H2NR1H3MAPTNPSR1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411000-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010110817-A1 | PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |