Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9383340 | 0.88 | KDM4E (0.46) | CYP3A4CYP1A2ALDH1A1KDM4EMAPT | |
| SCHEMBL946827 | 0.87 | MKNK1 (0.47) | MKNK1MKNK2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL947436 | 0.77 | MKNK1 (0.45) | MKNK1MKNK2CYP3A4CYP2C19CYP1A2 | |
| SCHEMBL18496709 | 0.74 | CAMKK2 (0.53) | — | |
| SCHEMBL946085 | 0.73 | MKNK1 (0.43) | MKNK1MKNK2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL868001 | 0.73 | KDM4E (0.44) | CYP3A4CYP1A2ALDH1A1GAAHCAR2 | |
| SCHEMBL25779250 | 0.72 | MKNK1 (0.53) | MKNK1MKNK2KMOCYP3A4CYP1A2 | |
| SCHEMBL27873010 | 0.72 | PTGS2 (0.49) | MKNK1MKNK2KMOCYP3A4CYP1A2 | |
| SCHEMBL19857473 | 0.72 | KDM4E (0.55) | CYP3A4CYP1A2ALDH1A1GAAKDM4E | |
| SCHEMBL28061001 | 0.71 | MKNK1 (0.51) | MKNK1MKNK2CYP3A4CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | HOFFMANN-LA ROCHE INC. | 2007-08-23 | — | — | US | claimed |
| CN-102725290-B | As the condensed heterocyclic compouds of ion channel modulators | GILEAD SCIENCES, INC. (US) | 2016-03-09 | — | — | CN | disclosed |
| CN-102725290-A | Fused heterocyclic compounds as ion channel modulators | GILEAD PALO ALTO INC | 2012-10-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197553-A1 | 4-Aryl-pyridine-2-carboxyamide derivatives | GRM2, GRM1, GRM3 | MKNK1 3419/4885MKNK2 2611/4885KMO 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.