Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158719 | 0.95 | KDM4E (0.41) | TACR1SIGMAR1TMEM97KDM4ECCNT1 | |
| SCHEMBL5162344 | 0.92 | SIGMAR1 (0.39) | TACR1SIGMAR1TMEM97KDM4ECCNT1 | |
| SCHEMBL5158527 | 0.91 | TACR1 (0.39) | TACR1SIGMAR1TMEM97KDM4ECCNT1 | |
| SCHEMBL6482708 | 0.91 | SIGMAR1 (0.41) | TACR1SIGMAR1TMEM97KDM4ECCNT1 | |
| SCHEMBL5161802 | 0.90 | TACR1 (0.40) | TACR1SIGMAR1TMEM97KDM4ECCNT1 | |
| SCHEMBL5158817 | 0.90 | TACR1 (0.46) | TACR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5160981 | 0.89 | CCR5 (0.36) | TACR1SIGMAR1KDM4ECCNT1CDK9 | |
| SCHEMBL5161363 | 0.88 | KCNH2 (0.40) | TACR1 | |
| SCHEMBL5156763 | 0.88 | TACR3 (0.40) | TACR1SIGMAR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5158660 | 0.88 | TACR1 (0.39) | TACR1SIGMAR1TMEM97KDM4ECCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256164-A1 | NK1 and NK3 antagonists | PFIZER INC | 2005-11-17 | — | — | US | claimed |
| EP-1748984-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | Pfizer Products Inc. (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005110987-A1 | PIPERIDINE DERIVATIVES AS NK1 AND NK3 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050256164-A1 | NK1 and NK3 antagonists | PFIZER INC | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256164-A1 | NK1 and NK3 antagonists | TAC3, TACR1, TACR2 | TACR1 2/4885SIGMAR1 779/4885TMEM97 1104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.