SCHEMBL5157380

SCHEMBL5157380

CCCOc1ccccc1C(=O)OC(=O)Oc1ccc(C(C)(C)c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.45
NPSR1 Q6W5P4 1/20 0.45
MEN1 O00255 7/20 0.44
KMT2A Q03164 7/20 0.44
HIF1A Q16665 1/20 0.44
KDM4E B2RXH2 10/20 0.44
POLB P06746 2/20 0.44
ALDH1A1 P00352 8/20 0.43
HTT P42858 2/20 0.43
SMN1; SMN2 Q16637 5/20 0.42
GAA P10253 1/20 0.42
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRB3 P13945 1/20 0.41
LMNA P02545 3/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5155893 0.88 ALDH1A1 (0.50) MAPTNPSR1MEN1KMT2AHIF1A
SCHEMBL5157734 0.84 MEN1 (0.51) MAPTNPSR1MEN1KMT2AHIF1A
SCHEMBL1009321 0.80 ADRB2 (0.53) MAPTNPSR1MEN1KMT2AHIF1A
SCHEMBL5705988 0.78 MAPT (0.48) MAPTNPSR1MEN1KMT2AKDM4E
SCHEMBL4343858 0.78 ESR1 (0.51) MAPTNPSR1MEN1KMT2APOLB
SCHEMBL26125296 0.77 ALDH1A1 (0.55) MAPTNPSR1MEN1KMT2AHIF1A
SCHEMBL9769816 0.76 MAPT (0.62) MAPTNPSR1MEN1KMT2AKDM4E
Bicarbonate SCHEMBL7114860 0.76 ESR1 (0.50) MAPTNPSR1MEN1KMT2APOLB
Bicarbonate SCHEMBL29983692 0.76 ALDH1A1 (0.54) MAPTNPSR1MEN1KMT2AHIF1A
SCHEMBL3977783 0.76 KMT2A (0.53) MAPTNPSR1MEN1KMT2AHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7259223-B2 Process for the production of polycarbonate GENERAL ELECTRIC COMPANY (US) 2007-08-21 US disclosed
EP-1360220-B1 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GEN ELECTRIC (US) 2007-01-31 EP disclosed
US-20040220352-A1 Process for the production of polycarbonate SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2004-11-04 US disclosed
EP-1360220-A2 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2003-11-12 EP disclosed
US-20020132957-A1 Process for the production of polycarbonate GENERAL ELECTRIC COMPANY 2002-09-19 US disclosed
WO-2002060855-A2 PROCESS FOR THE PRODUCTION OF POLYCARBONATE GENERAL ELECTRIC COMPANY (US) 2002-08-08 WO disclosed