SCHEMBL5157971

SCHEMBL5157971

CCN1c2cc(C(F)(F)F)ccc2N(CC)c2c1ccc(C)c2C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.36
MAPT P10636 4/20 0.36
NPSR1 Q6W5P4 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 1/20 0.36
XBP1 P17861 1/20 0.34
FFAR4 Q5NUL3 1/20 0.33
HSP90AA1 P07900 1/20 0.33
PKM P14618 1/20 0.33
LMNA P02545 2/20 0.32
HTR7 P34969 1/20 0.32
TSHR P16473 2/20 0.32
KMT2A Q03164 2/20 0.31
POLB P06746 1/20 0.31
P2RX7 Q99572 1/20 0.31
TP53 P04637 2/20 0.31
NPC1 O15118 1/20 0.31
ABCB11 O95342 1/20 0.31
CYP1A2 P05177 1/20 0.31
CHRM2 P08172 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5070055 0.88 MAPT (0.40) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL5140612 0.71 MAPT (0.37) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL29865250 0.70 TP53 (0.47) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL17353592 0.70 TP53 (0.47) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL1755260 0.68 PDE2A (0.46) ALDH1A1MAPTTSHRTP53MAPK1
SCHEMBL17356867 0.68 MAPK1 (0.42) ALDH1A1MAPTNPSR1SMN1; SMN2XBP1
SCHEMBL5070034 0.66 ALDH1A1 (0.41) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL16067356 0.64 HTR7 (0.39) ALDH1A1FFAR4PKMHTR7P2RX7
SCHEMBL21445198 0.64 TP53 (0.67) ALDH1A1MAPTNPSR1SMN1; SMN2HPGD
SCHEMBL12849193 0.63 PPARG (0.44) MAPTSLC6A4KCNH2HTR2APDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1457813-B1 An improved electrochromic medium capable of producing a pre-selected color GENTEX CORP (US) 2007-01-24 EP disclosed
EP-1457813-A2 An improved electrochromic medium capable of producing a pre-selected color Gentex Corporation (US) 2004-09-15 EP disclosed
EP-0972227-B1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORP (US) 2004-07-14 EP disclosed
US-6037471-A FOR ELECTROCHROMIC MIRRORS FOR MOTOR VEHICLES GENTEX CORPORATION (US) 2000-03-14 US disclosed
US-6020987-A Electrochromic medium capable of producing a pre-selected color GENTEX CORPORATION (US) 2000-02-01 US disclosed
EP-0972227-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 2000-01-19 EP disclosed
US-5998617-A MIXTURE OF ELECTROACTIVE MATERIALS AT PRESELECTIVE CONCENTRATION; GRAY COLOR GENTEX CORPORATION (US) 1999-12-07 US disclosed
WO-1998044384-A1 AN IMPROVED ELECTROCHROMIC MEDIUM CAPABLE OF PRODUCING A PRE-SELECTED COLOR GENTEX CORPORATION (US) 1998-10-08 WO disclosed