Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL27600502 | 0.96 | — | — | |
| Glycine SCHEMBL28208007 | 0.93 | — | — | |
| Glycine SCHEMBL13169653 | 0.91 | — | — | |
| Glycine SCHEMBL93765 | 0.91 | GLRA1 (1.00) | — | |
| Glycine SCHEMBL29385054 | 0.91 | — | — | |
| Glycine SCHEMBL2116443 | 0.91 | — | — | |
| Glycine SCHEMBL6675874 | 0.91 | GLRA1 (1.00) | — | |
| Glycine SCHEMBL391027 | 0.91 | GLRA1 (1.00) | — | |
| Glycine SCHEMBL391786 | 0.91 | GLRA1 (1.00) | — | |
| Glycine SCHEMBL6163 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1398023-B1 | Antiperspirant composition and method of preparation thereof | REHEIS INC (US) | 2006-10-11 | — | — | EP | claimed |
| EP-1398023-A1 | Antiperspirant composition and method of preparation thereof | REHEIS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| US-6649153-B1 | Skin friendly antiperspirant composition and method of making | REHEIS INC. | 2003-11-18 | — | — | US | claimed |
| EP-1814508-A1 | ACTIVATED ALUMINUM/DEPOLYMERIZED ZIRCONIUM ANTIPERSPIRANT COMPOSITIONS | REHEIS, INC. (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1374844-B1 | Amino acid free stable aluminum/zirconium antiperspirant solution | REHEIS INC (US) | 2007-02-07 | — | — | EP | disclosed |
| US-7144571-B2 | Amino acid free stable aluminum/zirconium antiperspirant solution | REHEIS, INC. (US) | 2006-12-05 | — | — | US | disclosed |
| EP-1398023-B1 | Antiperspirant composition and method of preparation thereof | REHEIS INC (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2006046945-A1 | ACTIVATED ALUMINUM/DEPOLYMERIZED ZIRCONIUM ANTIPERSPIRANT COMPOSITIONS | REHEIS INC. (US) | 2006-05-04 | — | — | WO | disclosed |
| US-6960338-B2 | Amino acid free stable aluminum/zirconium antiperspirant solution | REHEIS, INC. (US) | 2005-11-01 | — | — | US | disclosed |
| US-20050186163-A1 | Amino acid free stable aluminum/zirconium antiperspirant solution | GENERAL CHEMICAL CORPORATION | 2005-08-25 | — | — | US | disclosed |
| US-6835374-B2 | Fine particle size; mixing, suspension active material with surfactant | REHEIS, INC. | 2004-12-28 | — | — | US | disclosed |
| EP-1024781-B1 | ENHANCED EFFICACY STABLE ANTIPERSPIRANT ACTIVE SOLUTION AND METHOD OF MAKING SAME | WESTWOOD CHEMICAL CORP (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6416750-B1 | MIXING ALUMINUM CHLOROHYDRATE, WATER, AND DIOL SOLVENT, SPRAY DRYING TO FORM POWDER, AND DISSOLVING INTO 1,2-DIOL SOLVENT (1,2-HEXANEDIOL); INCREASED FORMULATION FLEXIBILITY; LESS ENERGY INTENSIVE PROCESS | SOMERVILLE TECHNOLOGY GROUP, INC. | 2002-07-09 | — | — | US | disclosed |
| EP-1087748-B1 | METHOD OF MAKING ANTIPERSPIRANT POWDERS | GILLETTE CO (US) | 2002-05-02 | — | — | EP | disclosed |
| EP-1087748-A1 | METHOD OF MAKING ANTIPERSPIRANT POWDERS | THE GILLETTE COMPANY (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6126927-A | Method of making antiperspirant powders | THE GILLETTE COMPANY (US) | 2000-10-03 | — | — | US | disclosed |
| EP-1024781-A1 | ENHANCED EFFICACY STABLE ANTIPERSPIRANT ACTIVE SOLUTION AND METHOD OF MAKING SAME | WESTWOOD CHEMICAL CORPORATION (US) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999065457-A1 | METHOD OF MAKING ANTIPERSPIRANT POWDERS | THE GILLETTE COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| US-5955064-A | BLENDING AN ENHANCED BASIC ALUMINUM CHLOROHYDRATE WITH A ZIRCONIUM HYDROXYHALIDE NEUTRAL AMINO ACID COMPLEX | WESTWOOD CHEMICAL CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| WO-1999020240-A1 | ENHANCED EFFICACY STABLE ANTIPERSPIRANT ACTIVE SOLUTION AND METHOD OF MAKING SAME | WESTWOOD CHEMICAL CORPORATION (US) | 1999-04-29 | — | — | WO | disclosed |