Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.44 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.44 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30343291 | 0.87 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL599994 | 0.87 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| SCHEMBL11694301 | 0.85 | NPC1 (0.62) | NPC1RAB9AATMHSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL6131224 | 0.84 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Bromide SCHEMBL5144105 | 0.84 | NPC1 (0.61) | NPC1RAB9AATMHSD17B10TDP1 | |
| Hydrochloric Acid SCHEMBL31173710 | 0.84 | NPC1 (0.65) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16650533 | 0.82 | ATM (0.64) | NPC1RAB9AATMACHEHSD17B10 | |
| SCHEMBL741714 | 0.82 | NPC1 (0.62) | NPC1RAB9AATMACHETDP1 | |
| Hydrochloric Acid SCHEMBL8068701 | 0.82 | NPC1 (0.67) | NPC1RAB9AATMTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10444520 | 0.81 | NPC1 (0.61) | NPC1RAB9AATMTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8295658-A | — | — | None | — | — | JP | disclosed |
| EP-1473330-B1 | Process for the synthesis of oxonol compound | FUJI PHOTO FILM CO LTD (JP) | 2007-02-14 | — | — | EP | disclosed |
| EP-0819977-B1 | Oxonol compound and silver halide photographic material | FUJI PHOTO FILM CO LTD (JP) | 2006-01-04 | — | — | EP | disclosed |
| EP-1473330-A1 | Process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6159673-A | Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 2000-12-12 | — | — | US | disclosed |
| US-6060228-A | BACKING LAYER CONTAINS A METHINE DYE HAVING SPECIFIC MAXIMUM ABSORPTION WAVELENGTH | FUJI PHOTO FILM CO., LTD. (JP) | 2000-05-09 | — | — | US | disclosed |
| EP-0819977-A1 | Oxonol compound, silver halide photographic material and process for the synthesis of oxonol compound | FUJI PHOTO FILM CO., LTD. (JP) | 1998-01-21 | — | — | EP | disclosed |
| JP-H08295658-A | PRODUCTION OF PENTAMETHINE COMPOUND AND QUATERNARY SALT COMPOUND | SANKYO KAGAKU KK | 1996-11-12 | — | — | JP | disclosed |
| US-5459265-A | Oxonol dye | FUJI PHOTO FILM CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |