Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 4/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1764416 | 1.00 | TSHR (0.58) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL1764363 | 0.86 | ALDH1A1 (0.58) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL21483641 | 0.79 | TSHR (0.62) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL13307075 | 0.78 | TSHR (0.56) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL9419624 | 0.75 | PIM1 (0.51) | MEN1KMT2A | |
| SCHEMBL9787326 | 0.74 | TSHR (0.60) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL29354025 | 0.73 | TSHR (0.51) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL3401752 | 0.73 | TSHR (0.51) | TSHRHTTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL1763884 | 0.72 | DRD2 (0.57) | TSHRALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL319893 | 0.72 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AF10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751116-A2 | PYRIMIDINE COMPOUNDS AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005118558-A2 | PYRIMIDINE COMPOUNDS AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2005-12-15 | — | — | WO | disclosed |