Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858500 | 0.89 | LMNA (0.38) | HCAR3ALDH1A1KDM4ECYP1A2TSHR | |
| SCHEMBL3860981 | 0.86 | HCAR3 (0.49) | HCAR3ALDH1A1TSHRSMN1; SMN2CNR1 | |
| SCHEMBL3857572 | 0.83 | ALDH1A1 (0.43) | HCAR3ALDH1A1KDM4ECYP1A2TSHR | |
| SCHEMBL3856420 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ECYP1A2TSHRCYP2C19 | |
| SCHEMBL3350040 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4ELMNACNR1MAPT | |
| SCHEMBL3855487 | 0.76 | KDM4E (0.39) | HCAR3ALDH1A1KDM4ECYP1A2TSHR | |
| SCHEMBL1816292 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KDM4ECYP1A2TSHRCYP2C19 | |
| SCHEMBL1579300 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNAL3MBTL1 | |
| SCHEMBL3854447 | 0.74 | POLB (0.39) | HCAR3ALDH1A1KDM4ECYP1A2TSHR | |
| SCHEMBL3720398 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |