Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 12/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14465845 | 0.90 | TLR7 (0.60) | TLR7TLR8CNR2BRD4 | |
| SCHEMBL4792564 | 0.84 | TLR7 (0.52) | TLR7TLR8KDM4EALDH1A1NPSR1 | |
| SCHEMBL4792602 | 0.84 | TLR7 (0.69) | TLR7TLR8BRD4 | |
| SCHEMBL4761822 | 0.83 | ALDH1A1 (0.46) | TLR7KDM4EALDH1A1NPSR1HSD17B10 | |
| SCHEMBL4763937 | 0.83 | TLR7 (0.52) | TLR7TLR8KDM4EALDH1A1NPSR1 | |
| SCHEMBL5160125 | 0.82 | TLR7 (0.46) | TLR7LMNAMAPTHPGDSMN1; SMN2 | |
| SCHEMBL14465833 | 0.82 | TLR7 (0.52) | TLR7TLR8KDM4EALDH1A1NPSR1 | |
| SCHEMBL14466847 | 0.81 | TLR7 (0.54) | TLR7TLR8CNR2LMNABRD4 | |
| SCHEMBL5159479 | 0.80 | TLR7 (0.82) | TLR7TLR8 | |
| SCHEMBL14466065 | 0.78 | TLR7 (0.62) | TLR7TLR8CNR2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765348-A2 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES | 3M Innovative Properties Company (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006028545-A2 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZOPYRIDINES, AND IMIDAZONAPHTHYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-03-16 | — | — | WO | disclosed |