SCHEMBL5160650

SCHEMBL5160650

O=C(O)C(OC1CCCNC1)(c1ccccc1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.42
NFE2L2 Q16236 1/20 0.42
KMT2A Q03164 1/20 0.41
CHRNB2 P17787 4/20 0.39
CHRNA4 P43681 4/20 0.39
CHRNB4 P30926 2/20 0.38
CHRNA3 P32297 2/20 0.38
HTR1A P08908 1/20 0.38
SLC6A2 P23975 1/20 0.38
KDM4E B2RXH2 1/20 0.37
NPC1 O15118 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
HPGD P15428 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP2C19 P33261 1/20 0.37
RAB9A P51151 1/20 0.37
CHEK1 O14757 1/20 0.37
KCNH2 Q12809 1/20 0.37
SLC6A1 P30531 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5161390 0.76 CHRM2 (0.59) CYP2D6CYP2C19RAB9AKCNH2LMNA
SCHEMBL16759127 0.72 CHRNA7 (0.55) KMT2ACHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL13500109 0.72 KEAP1 (0.49) KEAP1NFE2L2KMT2ACHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6621806 0.71 CHRNA7 (0.54) KMT2ACHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL16759124 0.70 KMT2A (0.48) KMT2ACHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL26970072 0.70 KEAP1 (0.46) KEAP1NFE2L2KMT2ACHRNB2CHRNA4
SCHEMBL16759167 0.70 KMT2A (0.48) KMT2A
SCHEMBL6425440 0.69 CYP3A4 (0.57) KDM4ECYP1A2CYP2D6MAPK1SLC6A1
Trifluoroacetic Acid SCHEMBL16758816 0.69 KMT2A (0.42) KMT2AHTR1ASLC6A2CHRM3
SCHEMBL999781 0.69 FAAH (0.54) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11152270-A None JP disclosed
EP-1275645-B1 LABELED COMPOUNDS FOR MEASURING THE FUNCTION OF THE MUSCARINIC ACETYLCHOLINE NERVOUS SYSTEM HAMAMATSU PHOTONICS KK (JP) 2007-02-28 EP disclosed
EP-1275645-A1 LABELED COMPOUNDS FOR MEASURING THE FUNCTION OF THE MUSCARINIC ACETYLCHOLINE NERVOUS SYSTEM HAMAMATSU PHOTONICS K. K. (JP) 2003-01-15 EP disclosed
JP-H11152270-A MUSCARINIC ACETYLCHOLINE NERVOUS SYSTEM LABELED COMPOUND AND ITS SYNTHESIS HAMAMATSU PHOTONICS KK 1999-06-08 JP disclosed