Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5929551 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAL3MBTL1KDM4EGRM8 | |
| Hydrochloric Acid SCHEMBL6773597 | 0.82 | GRM8 (0.46) | SMN1; SMN2LMNAL3MBTL1KDM4EGRM8 | |
| Hydrochloric Acid SCHEMBL6779703 | 0.82 | GRM8 (0.46) | SMN1; SMN2LMNAL3MBTL1KDM4EGRM8 | |
| SCHEMBL7056950 | 0.81 | LMNA (0.52) | LMNAKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL687445 | 0.81 | LMNA (0.52) | LMNAKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL295743 | 0.81 | LMNA (0.52) | LMNAKDM4EGAAALDH1A1KMT2A | |
| SCHEMBL9159608 | 0.81 | CYP2C19 (0.46) | SMN1; SMN2LMNAL3MBTL1KDM4EGRM8 | |
| SCHEMBL5929629 | 0.80 | LMNA (0.42) | SMN1; SMN2LMNAKDM4EGRM8GRM4 | |
| SCHEMBL5162907 | 0.80 | LMNA (0.42) | SMN1; SMN2LMNAKDM4EGRM8GRM4 | |
| SCHEMBL235125 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAL3MBTL1KDM4EGRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |